- TUDCA should be used along with any oral compounds requiring extensive metabolism to reduce stress on the liver and to act as an antioxidant aiding all healthy cells in the body.*
- TUDCA helps in protecting humans from cholestasis (reduction or stoppage of bile flow) because it can break down fats resulting in a healthy liver.*
- TUDCA has been shown by research to improve liver healing rates in both steatotic and non-steatotic livers.*
- TUDCA is helpful in weight loss so it may be beneficial to people with fatty liver or those who want to lose body fat.*
- TUDCA also helps to control cholesterol levels in the liver.*
MuscleSport TUDCA (Tauroursodeoxycholic acid) is a water-soluble bile acid that shows great ability to treat liver cholestasis (bile acid accumulation and backup in the liver) via counteracting the toxicity of regular bile acids. These toxic bile salts can be damaging to cells by destroying the membranes and signaling for cell death. TUDCA supplements compete with this toxicity and thus indirectly protect cells from death. TUDCA is especially beneficial for those engaged in a strength training program who also take oral performance enhancement products. These products can often inhibit the production and flow of bile from the liver which can have long-term, negative consequences.
- Reduces liver and endoplasmic reticulum stress.
- Enhances insulin sensitivity.
- Helps eliminate toxins and protect against potentially harmful oral compounds.
- May offer neuroprotective effects.
TUDCA supplementation may also reduce endoplasmic reticulum stress throughout the body, not just in the liver. The endoplasmic reticulum is the organelle within cells that transports proteins out of cells. As a result, there are widespread uses of TUDCA for potentially enhancing nitrogen balance, reducing cholesterol, increase neuroprotection, and positively influence thyroid hormones in fat loss. In addition, research on daily TUDCA supplementation has found huge increases to insulin sensitivity! The 30% increase in insulin sensitivity in this study is one of the greatest on record.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Invernizzi, P., Setchell, K. D., Crosignani, A., Battezzati, P. M., Larghi, A., O'Connell, N. C., & Podda, M. (1999). Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine‐conjugated species in patients with primary biliary cirrhosis. Hepatology, 29(2), 320-327.
Crosignani, A., Budillon, G., Cimino, L., Del, C. V. B., Loguercio, C., Ideo, G., ... & Podda, M. (1998). Tauroursodeoxycholic acid for the treatment of HCV-related chronic hepatitis: a multicenter placebo-controlled study. Hepato-gastroenterology, 45(23), 1624-1629.
Crosignani, A., Battezzati, P. M., Setchell, K. D., Invernizzi, P., Covini, G., Zuin, M., & Podda, M. (1996). Tauroursodeoxycholic acid for treatment of primary biliary cirrhosis. Digestive diseases and sciences, 41(4), 809-815.
Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., ... & Klein, S. (2010). Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes.
Panella, C., Ierardi, E., De, M. M., Barone, M., Guglielmi, F. W., Polimeno, L., & Francavilla, A. (1995). Does tauroursodeoxycholic acid (TUDCA) treatment increase hepatocyte proliferation in patients with chronic liver disease?. The Italian journal of gastroenterology, 27(5), 256-258.
Keene, C. D., Rodrigues, C. M., Eich, T., Chhabra, M. S., Steer, C. J., & Low, W. C. (2002). Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease. Proceedings of the National Academy of Sciences, 99(16), 10671-10676.
Hardison, W. G., & Grundy, S. M. (1984). Effect of ursodeoxycholate and its taurine conjugate on bile acid synthesis and cholesterol absorption. Gastroenterology, 87(1), 130-135.
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